1ZBPage  of 4 - "Magnesium for Energy" MAGNESIUM - ACTIVATOR FOR ENERGY Photocopied out of his British medical journal by Dr. Villet and given to Rev. Smiley T. Papenfus, who put this most inofmative document in Layman's terms with the assistance of Websters dictionary - all Websters definitions are in itallics Magnesium Chloride freely available from:- U.S.A. - Wal-Mart in the form of Slow-Mag tablets - 3 to 6 tablets a day taken three times daily. Magnesium Chloride crystals freely available from:- U.S.A. - Gallipod Pharmaceuticals: 800.423.6967 - Diana - $19,95 for 1lb or $74,80 for 5 lbs - I've recently been informed that you need a prescription to get it from the U.S.A. supplier - the South African route is your best bet - and much cheaper too. If one really needed to have a prescription for Magnesium-Chloride, which is simply an essential mineral, then you should also need a prescription for a bottle of multi-vitamin/multi-mineral tablets you buy over the counter at Wal-Mart - it makes no sense to me - all these tablets contain Magnesium - Magnesium-Chloride is just a form of Magnesium that has been proven to have superior absorbtion by the body (chloride is salt). South Africa - Medicon: 5 Bessemer Rd, Amalgam, Johannesburg, 2092, South Africa Tel: from the USA dial 011 first - then 27.11.839.3142 Mon-Fri, 8:30am-4:30pm - South Africa is 7 hrs ahead of US Eastern Time. Calling Rate from the USA is $1.00 per minute - unless you setup a special overseas rate with AT&T or MCI at 35c per minute, which is freely available OR join VIP (800.836.5007) for a rate of 15c per minute. VIP has the greatest international calling plan - no changing of service provider necessary - see their web-site... http://www.joinvip.com Email: ??? - if you discover their Email address please Email that information to Smiley - smiley@laymanstraining.com - or Fax it to me 813.654.7606 U.S.A. Price: R115,00 ( $20,00 US) for 5 x 500g bottles Postage: $20 (delivery should take approximately 2 weeks) 5 Bottles of these {salt like} crystals will last one person approximately 2 years (i.e. your cost is $1,66 per month - the best $1.66 you'll ever spend on your health) - which will become very clear at the end of this document. Dose: a small teaspoon per gallon of pure water, to be consumed within 1-2 days. I stumbled across the idea to put Magnesium-Chloride into my daily drinking water when I was traveling through Missouri, and noticed the label on the bottle of drinking water I bought from 'Krogers' read, "Magnesium Chloride added for taste". If you put more than 1 teaspoon per gallon, the taste can be a bit too strong - but with just a teaspoon you won't hardly notice it - in fact it takes the blandness out of water - now I can't stand water without it - yuk! Also, Dr. W. Davis (South Africa's #1 specialist physician) stressed you need to take your 6 "SlowMag" tablets throughout the day, not all at once in the morning. As this is not practical for most folks, you can achieve this by carrying a bottle of drinking water, dosed with Magnesium Chloride, with you wherever you go, and sip it continually throughout the day. NB. Many long distance runners have taped into the benefit of swallowing a "SlowMag" tablet every hour during a marathon, giving them amazing energy and endurance. For those who can't get Magnesium-Chloride crystals... Alternative U.S.A. Suppliers: Walgreens or Eckerd Pharmacies - ask for "SlowMag" tablets. Alternative S.A. Suppliers: Any Pharmacy - ask for "SlowMag" tablets. Take one to two tablets, 3 times a day after meals. NB. If you don't have time to read this article, at least skim through the Boldtype and underlined text. Here is the most amazing excerpt from this article on the benefits of taking Magnesium-Chloride... For many of us in general practice this would be equivalent to a resurrection from the dead. Whoever would expect to find such a bold statement in a British medical journal - certainly not me - but it's true. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Besides Magnesium-Chloride, 5 other essential products for a healty heart can be found on the web-site... www.laymanstraining.com/hot_links.html ...PageDn to set 4 of 6. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ The inherent power Magnesium Cholride has to produce incredibly high ENERGY levels Physiological ([fizEE uh loj_i kuhl) consistent with the normal functioning of an organism) aspects of magnesium. It comes as no surprise that the Egyptians were sun-worshippers when one considers our utter dependence on its ENERGY for life upon earth. And central to the utilisation of its ENERGY lies the formula for chlorophyll ([(klr_uh fil] green pigment of plant leaves essential to production of carbohydrates and photsynthesis). And central, again, to chlorophyll is the element Magnesium. Haem (part of haemoglobin) has a formula in common with all the porphyrins ([pr_fuh rin] a dark red, photosensitive pigment consisting of four pyrrole rings linked by single carbon atoms: a component of chlorophyll, heme, and vitamin B12), but here iron is the core. In man magnesium is, however still central as an essential element for the utilisation of ENERGY, but rather because it is the activator of more than 300 enzymatic reactions which control various stages of bodily function in the persistent quest to hold on to life. The cells of man are heterotrophic ([het_uhr uh trof] an organism requiring organic compounds for its principal source of food) in contrast to the autotrophic cells of plants, and therefore require their fuels in specially prepared forms to generate the ENERGY, i.e. carbohydrates, proteins and fats. These are, however, only potential sources of ENERGY and require catabolism (destructive metabolism, the breaking down of complex substances into simpler ones with the release of ENERGY) to be formed to usable ENERGY, i.e. ATP (Adenosine Tri-phosphate). (Dr. W. Davis' big theme). The high-ENERGY phosphate (salt) bonds are clearly indicated as a wavy line, and their dissolution releases ENERGY. Magnesium is an essential cofactor in this dissolution or Hydrolysis ([(hI drol_uh sis] Chemical decomposition in which a compound is split into other compounds by reacting with water) as well as in the formation of ATP anew or Phosphorylation (to introduce the trivalent group = P = O into an organic compound having a chemical varience of 3). Magnesium and ATPase (Adenosine triphosphatase enzyme) The enzyme, Mg-ATPase, has been isolated from the membranes of many cells. It catalyses the hydrolysis of ATP to ADP (Adenosine Diphosphate) releasing necessary ENERGY. The implication of inadequate magnesium for all the processes throughout the body which require the ENERGY of ATP is far-ranging. Amongst others, it affects the all-important transport of sodium, potassium and therefore water via the "sodium-potassium pump". The ATPase of this pump is an enzyme complex that offers a binding-site for ATP. The alpha-particles bind ATP which is hydrolysed, as the enzyme complex (Ei) is phosphorylised. This pumps sodium out (extracellular) and potassium in (B). With magnesium, Calcium is also essential, and the two are always found to be in opposition to one another, or, on more friendly terms, in homeostasis ([hOmEE uh stAY_sis] a state of psychological equilibrium obtained when tension or a drive has been reduced or eliminated). The thermostats of our bodies are regulated by the thyroid hormone, principally through control of the process of oxydative phosphorylation ([fos_fuhr uh lAYt] to introduce the trivalent group = P = O into an organic compound), which requires magnesium as cofactor. ATP group of molecules, a nucleotide ([nU_klEE uh tId] any of a group of molecules that, when linked together, form the building blocks of DNA or RNA: in DNA the group comprises a phosphate group, the bases adenine, cytosine, guanosine, and thymine, and a pentose sugar; in RNA the thymine base is replaced by uracil) is the primary source of ENERGY in all living cells because of its function in donating a phosphate group during bio chemical activities. ADP is a nucleotide that functions in the transfer of ENERGY during the catabolism of glucose. MAGNESIUM AND CARBOHYDRATE METABOLISM Magnesium is also found to be an essential requirement in the metabolism of carbohydrates. (a) Glycogenesis and Glycogenolysis For many of us in general practice this would be equivalent to a resurrection from the dead. Glycogenolysis (Embden-Meyerhof cycle): Glucose is used very quickly in muscle and serum and therefore glycogen needs to be broken down to glucose by phosphorylation (again). Magnesium is the essential cofactor. This principally takes place in the liver and, less so, in muscle. Glycogenesis: Glycogen is the form whereby glucose is stored, in liver, muscle and fat. Again, the process is phosphorylation, by the enzyme glucokinase ([glUkO kI_nAYs] an enzyme that catalyzes the phosphorylation of glucose), and magnesium is essential as activator. The implications of magnesium for ENERGY from carbohydrate is important, including the role of this element in diabetes and hypoglycemia. We will return to these diagrams because we can see from the Embden-Meyerhof cycle that two pathways end in triglycerides (fats) and amino acid (therefore proteins). Here the story endeth not! (b) The Pentose Monophosphate cycle This cycle is necessary for the formation of varios substances required in the synthesis (the combining of separate elements into a whole) of cells (eg sedoheptulose, fructose-6-phosphate, ribose and de-oxyribose, the latter essential for RNA and DNA). It is also the most important source of hydrogen and carbon dioxide required for fatty acid synthesis in certain tissues. Magnesium is essential (with manganese) for the action of glucose-6-phsophate dehydrogenase. The implication for health is not certain. MAGNESIUM AND FAT METABOLISM We have already seen that the formation of triglycerides (fats) is dependent on the glycerol ([glis_uh rl] a colorless liquid, C3H8O3, used as a sweetener and preservative, and in suppositories and skin emollients) supplied by carbohydrate, where magnesium is essential. These neutral fats are the most important source of ENERGY. Triglycerides are broken down to glycerol and fatty acids. Co-enzyme A, usually written CoA-SH, activates fatty acids in the presence of thiokinase, ATP and magnesium, live rating ENERGY. The process is called beta-oxidation. NB. The implication for ENERGY-loss (tiredness, lassitude) and abnormal fatty acid metabolism as in diabetes, is important. To synthesise triglycerides the ENERGY of ATP to ADP is required, as well as the hydrolysis which requires magnesium, CoA-SH, as well as ATP and Magnesium is again required in the synthesis of cholesterol, which is essential for the formation of steroid hormones and bile salts. MAGNESIUM AND PROTEIN METABOLISM The Embden-Meyerhof cycle also leads to the formation of amino acids. Magnesium is, however, also directly involved in the synthesis of amino acids which require many enzymic reactions. As an example, we have the formation of the purines. Ribose-5-phosphate is changed via 11 equations to IMP (Inosine Monophosphate) and in 6 of these equations magnesium is an essential activator. IMP is changed to AMP (Adenosine Monophosphate) via 4 further equations, in which magnesium is required in the last. AMP is, of course, the basis for the formation of the all-important ATP. The purines are also essential elements of the nucleic acids and nucleotides - the "brain" of all cells. MAGNESIUM AND THE FINAL COMMON METABOLIC CYCLE (KREBS) We shall have to glance at a figure of this cycle to understand its importance (figure 8) Our old friends, the Embden-Meyerhof cycle, and its connections with protein and fat metabolism appear in the upper section. Here, as we know, magnesium was intimately involved. Throughout the cycle we note the frequent occurrence of Co-A-SH, which requires the activation of magnesium. MAGNESIUM AND MUSCLE TISSUE NB. ATP is the immediate source of ENERGY, and, obviously, magnesium is involved. But this source is limited, and resynthesis of ATP is managed by creatine ([krEE_uh tEEn] an amino acid, C4H9N3O2, that is a constituent of the muscles of vertebrates and is phosphorylated to store ENERGY used for muscular contraction) phosphate (CP) where magnesium is required. Both CP and ATP are supplied continuously on demand from carbohydrates and protein metabolism as outlined previously. The unit of contraction is the byofibril. This consists of the proteins actin and myosin. Without going into the finer details, byosin contains binding sites for actin and ATP which enables contraction, giving you a better heart pump. Magnesium is utilised in the hydrolysis of ATP and also in its synthesis ([sin_thuh sis] the forming or building of a more complex chemical substance or compound from elements or simpler compounds). The impulse in a muscle is borne along through a system of tubes called the T-tubes and L-tubes, with a sacklike end, the cysterna, which contains a large amount of calcium ions. Calcium enables contraction and mangesium enables relaxation and rest. Relaxation is also dependent on the absence of calcium, and this is brought about by active transport enabled by the hydrolysis of ATP and the presence of magnesium. MAGNESIUM AND BONE TISSUE In the body the highest concentrations of magnesium occurs in bone (and then the muscle). This could be an indication of its importance in these tissues. In later articles in this series on magnesium we will be going into more detail and will therefore only offer the barest skeleton in this article. In the first place, the action of alkaline phosphatase, which regulates bone metabolism, especially phosphates, requires the activation of magnesium. Furthermore, calcium and magnesium compete for absorption via the influence of Vitamin D. High calcium absorption (and also high phosphate intake) leads to higher magnesium exertion (and inadequate absorption). Both Ca and Mg are involved in the formation of bone. Parathormone (TH) also affects magnesium via its influence on Ca and PO4, having an opposite effect to that on calcium. PTH stimulates the oseoclasts and bone resorption. On the same level calcitonin should be named. It stimulates oseoblasts and bone formation and decreases Ca and PO4 in the serum. In a later article the effects of these substances on each other and magnesium will be examined. An additional factor is the transmittance of nerve impulses on the motor-endplates as well as on nerve synapses. Calcium enables adequate release of transmitter substances and magnesium inhibits this. NB. In conclusion to this section on the general effects of magnesium in the body, it must be obvious that inadequate magnesium must have far-ranging effects in the body, which we will examine in greater detail in later articles. MAGNESIUM IS MANDATORY Magnesium is absolutely essential for life. It is the activator of many enzymes, and plays an important role in many ENERGY releasing and storing reactions involving carbohydrate, fat and protein. A sufficient daily intake of magnesium is therefore important by virtue of its functions of protein synthesis, impulse transmission and its role as part of the enzymatic system. Magnesium is an important KEY element in the biological world. Its atomic structure renders it more effective in the absorption and transfer of ENERGY than any other element. HYPOMAGNESAEMIA Clinical manifestation (symptoms) of magnesium "deficiency" include:- Loss of appetite Nausea Weakness Apathy Muscle fibrillation - uncontrolled twitching - fast or irregular heartbeat Tremors - involuntry shaking of the body or limbs Vertigo - a disordered conditoin in which you feel yourself or surroundings whirling around Depression Irritability Psychotic behavious - mental disorder DIETARY Subclinical hypomagnesaemia may be more common than is recognised. Dark green, leafy vegetables (dietary source of magnesium) are not common inclusions in everyday dishes. Also the magnesium content of meat is affected by boiling, roasting and frying. If the above symptoms are familiar to you.... ....consider hypomagnesaemia: prescribe SLOWMAG (i.e. Magnesium Chloride - Dr. W. Davis says this Magnesium-Chloride is by far the best magnesium to take as tests have proved in thousands of patients over many, many years). 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